UPDATE: The webinar is now available to watch online. Click here and follow the prompts to register
A few weeks back I had the pleasure of chatting to a few people at Seahorse Biosciences (now a part of the Agilent family) about what I considered to be some of the most important unanswered questions in terms of metabolic reprogramming and stem cells. My initial response was to ask if they had all day! Anyway, the conversation really got me thinking about some of the work that we were doing, and whether we were in fact trying to answer some of the most important questions.
In the time after my initial discussions with Seahorse, I stayed in regular contact about some of the questions we came up with and how we might go about answering them. It was at this point that my contact at Seahorse suggested that if we were talking about these issues there were likely others having the same conversations, so he proposed that I give an Agilent sponsored webinar that would cover the broad topic of stem cell metabolism. I have included the webinar outline, and some of the broad questions I will (try to!) address below, along with a link to register. If you watch the webinar live, you can ask me questions during a Q&A at the end of the webinar, if you can’t watch the webinar live then it will be freely available to watch after May 17.
Finally, if you have any questions after the webinar, feel free to post them below, and I’ll do my best to answer them!
Register here: https://goo.gl/tz9Ma7
One of the most important and unanswered questions in stem cell biology is how decisions regarding cell fate are regulated, specifically whether a cell undergoes self-renewal or commitment to a specific lineage. While the better part of the 20th century focused on the importance of cellular metabolism for the generation of energy, recent work has uncovered an essential role for metabolism in the generation of the building blocks (nucleotides, phospholipids, and amino acids) required by rapidly dividing cells. Additionally, the metabolite balance of both stem and differentiated cells has been found to directly influence the epigenome through post-translational modifications of histones, DNA and transcription factors. With the development of the Seahorse XF Analyzers the last decade has seen an explosion of interest in the process of stem (and cancer) cell metabolic reprogramming. The overall goals of better understanding the link between metabolism and cell identity is to improve stem cell transplantation and regenerative medicine, nuclear reprogramming, transdifferentiation, and stable ex vivo expansion of stem cells.
Topics to be covered:
- Why metabolism is important – thinking beyond cellular energetics.
- How metabolism changes in different stem cell populations (eSCs, iPSCs and adult SCs).
- How modulation of cellular metabolism can be used to drive reprogramming and/or differentiation.