UPDATED Agilent Webinar: A Metabolic Roadmap for Stem Cell Lineage Progression

UPDATE: The webinar is now available to watch online. Click here and follow the prompts to register

A few weeks back I had the pleasure of chatting to a few people at Seahorse Biosciences (now a part of the Agilent family) about what I considered to be some of the most important unanswered questions in terms of metabolic reprogramming and stem cells. My initial response was to ask if they had all day! Anyway, the conversation really got me thinking about some of the work that we were doing, and whether we were in fact trying to answer some of the most important questions.

In the time after my initial discussions with Seahorse, I stayed in regular contact about some of the questions we came up with and how we might go about answering them. It was at this point that my contact at Seahorse suggested that if we were talking about these issues there were likely others having the same conversations, so he proposed that I give an Agilent sponsored webinar that would cover the broad topic of stem cell metabolism. I have included the webinar outline, and some of the broad questions I will (try to!) address below, along with a link to register. If you watch the webinar live, you can ask me questions during a Q&A at the end of the webinar, if you can’t watch the webinar live then it will be freely available to watch after May 17.

Finally, if you have any questions after the webinar, feel free to post them below, and I’ll do my best to answer them!

Register here: https://goo.gl/tz9Ma7

Webinar outline:

One of the most important and unanswered questions in stem cell biology is how decisions regarding cell fate are regulated, specifically whether a cell undergoes self-renewal or commitment to a specific lineage. While the better part of the 20th century focused on the importance of cellular metabolism for the generation of energy, recent work has uncovered an essential role for metabolism in the generation of the building blocks (nucleotides, phospholipids, and amino acids) required by rapidly dividing cells. Additionally, the metabolite balance of both stem and differentiated cells has been found to directly influence the epigenome through post-translational modifications of histones, DNA and transcription factors. With the development of the Seahorse XF Analyzers the last decade has seen an explosion of interest in the process of stem (and cancer) cell metabolic reprogramming. The overall goals of better understanding the link between metabolism and cell identity is to improve stem cell transplantation and regenerative medicine, nuclear reprogramming, transdifferentiation, and stable ex vivo expansion of stem cells.

Topics to be covered:

  • Why metabolism is important – thinking beyond cellular energetics.
  • How metabolism changes in different stem cell populations (eSCs, iPSCs and adult SCs).
  • How modulation of cellular metabolism can be used to drive reprogramming and/or differentiation.

Predatory journals are phishing scams for scientists

We all get those emails that start “Dr esteemed Professor…” or “Greetings of the day….”, desperately wanting us to submit an article to their new “open-access” (aka massive fee) journal. Plenty has been written about predatory publishing previously so I don’t want to rehash that, but I received an email this morning that was just so bad, that I would like to record it here for posterity, feel free to post your own in the comments:

Dear Dr. James G Ryall,

Hope you are doing well.

I will be thankful if you could concern on my request.

I am pleased to inform you that Journal of Stem Cell Research & Therapeutics (2475-5540) is planning to release Volume 2 Issue 5 by the mid of May and we need only two articles to accomplish this issue. In fact I am afraid as I am having few days to release the issue. Hence I have chosen some illustrious people like you to support us for release the upcoming issue. So please support us with your contribution of 2 Page Mini Review/Short Communication towards publication in JSRT.

Your prompt submission sustains us a lot and impacts my ranking in end of this month.

Hope you understand my concern and your kind attention in this regard is highly appreciable.

Await your hopeful submission.

Best Regards,
Melissa Hawkins

PS*: In addition, we are accepting the thesis as eBooks and also videos towards publication in JSRT to fulfill our journal in all aspects.