Manuscripts to download

Here is a list of my current publications, links have been provided to PDF downloads (when allowed, opens in new window), or directs to PubMed.

  1. Mølck C, Ryall J, Failla LM, Coates JL, Pascussi JM, Heath JK, Stewart G & Hollande F (2016). The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism. Cancer Letters 383, 135-143.
  2. Giraud J, Failla LM, Pascussi JM, Lagerqvist EL, Ollier J, Finetti P, Bertucci F, Ya C, Gasmi I, Bourgaux JF, Prudhomme M, Mazard T, Ait-Arsa I, Houhou L, Birnbaum D, Pélegrin A, Vincent C, Ryall JG, Joubert D, Pannequin J & Hollande F (2016). Autocrine secretion of progastrin promotes the survival and self-renewal of colon cancer stem-like cells. Cancer Research 76, 3618-3628.
  3. Davey JR, Watt KI, Parker BL, Chaudhuri R, Ryall JG, Cunningham L, Qian H, Sartorelli V, Sandri M, Chamberlain J, James DE & Gregorevic P (2016). Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass. JCI Insight 1, e85477.
  4. Caretti G, Berghella L, Juan A, Latella L & Ryall J (2016). Epigenetic regulation shapes the stem cells state. Stem Cells International 2016, 8143407.
  5. Laker RC & Ryall JG (2016). DNA methylation in skeletal muscle stem cell specification, proliferation, and differentiation. Stem Cells International 2016, 5725927.
  6. Ryall JG, Cliff T, Dalton S & Sartorelli V (2015). Metabolic reprogramming of stem cell epigenetics. Cell Stem Cell 17, 651-662.
  7. Ryall JG, Dell’Orso S, Derfoul A, Juan A, Zare H, Feng X, Clermont D, Koulnis M, Gutierrez-Cruz G, Fulco M & Sartorelli V (2015). The NAD+-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells. Cell Stem Cell 16, 171-183.
  8. Rowlands BD, Lau CL, Ryall JG, Thomas DS, Klugmann M, Beart PM, Rae CD (2015). Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism. Journal of Neuroscience Research 93, 1147-1156.
  9. Church JE, Trieu J, Sheorey R, Chee AY, Naim T, Baum DM, Ryall JG, Gregorevic P & Lynch GS (2014). Functional β-adrenoceptors are important for early muscle regeneration in mice through effects on myoblast proliferation and differentiation. PLoS One 9, e101379.
  10. Koopman R, Ly CH & Ryall JG (2014). A metabolic link to skeletal muscle wasting and regeneration. Frontiers in Physiology 5, 1-11.
  11. Proserpio V, Fittipaldi R, Ryall JG, Sartorelli V & Caretti G (2013). The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. Genes & Development 27, 1299-1312.
  12. Ryall JG (2013). Metabolic reprogramming as a novel regulator of skeletal muscle development and regeneration. FEBS Journal 280, 4004-4013.
  13. Peserico A, Chiacchiera F, Grossi V, Matrone A, Latorre D, Simonatto M, Fusella A, Ryall JG, Finley LW, Haigis MC, Villani G, Puri PL, Sartorelli V & Simone C (2013). A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cellular and Molecular Life Sciences 70,  2015-2029.
  14. Ryall JG (2012).  The role of sirtuins in the regulation of metabolic homeostasis in skeletal muscle. Current Opinion in Clinical Nutrition & Metabolic Care 15, 561-566.
  15. van Der Poel C, Gosselin LE, Schertzer JD, Ryall JG, Swiderski K, Wondemaghen M & Lynch GS (2011). Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury. Journal of Inflammation 29, 41.
  16. Juan AH, Ryall JG*, DerfoulA*, Feng X*, Dell’Orso S*, Pasut A*, ZareH, Simone J, Rudnicki MA & Sartorelli V (2011). Polycomb Ezh2 controls self renewal and safeguards transcriptional identity of skeletal muscle stem cells. Genes & Development 25, 789-794.  *These authors contributed equally to this work.
  17. Murphy KT, Cobani V, Ryall JG, Krasney PA, Ibebunjo C & Lynch GS (2011). Acute antibody-directed myostatin inhibition attenuates disuse muscle atrophy and weakness in mice. Journal of Applied Physiology 110, 1065-1072.
  18. Ryall JG*, Murphy KT*, Snell SM, Nair L, Krasney PA, Ibebunjo C, Holden KS, Koopman R & Lynch GS (2010). Antibody-directed myostatin inhibition improves diaphragm in young, but not adult dystrophic mdx mice. American Journal of Pathology 176, 2425-2434. *These authors contributed equally to this work.
  19. Ryall JG, Church JE & Lynch GS (2010). A novel role for b-adrenoceptor signalling in skeletal muscle growth, development and regeneration. Clinical and Experimental Physiology and Pharmacology 37, 397-401.
  20. Pearen MA, Ryall JG, Lynch GS & Muscat GEO (2009). Expression profiling of skeletal muscle following acute and chronic b2-adrenergic stimulation: Implications for hypertrophy, metabolism and circadian rhythm. BMC Genomics 10, 448.
  21. Koopman R, Church JE, Ryall JG & Lynch GS (2009). The role of b-adrenoceptor signaling in skeletal muscle: therapeutic implications for muscle wasting disorders. Current Opinion in Clinical Nutrition and Metabolic Care 12, 601-606.
  22. Turpin SM, Ryall JG, Southgate RJ, Darby I, Hevener AL, Febbraio MA, Kemp BE, Lynch GS & Watt MJ (2009). Examination of ‘lipotoxicity’ in skeletal muscle of high-fat fed and ob/ob mice. Journal of Physiology 587, 1593-1605.
  23. Dzamko N, Schertzer JD, Ryall JG, Steel R, Macaulay L, Wee S, Chen Z, Michell BJ, Oakill J, Watt MJ, Beck-Jorgensen S, Lynch GS, Kemp BE & Steinberg GR (2008). AMPK independent pathways regulate fatty acid oxidation during muscle contraction. Journal of Physiology 586, 5819-5831.
  24. Gehrig SM, Ryall JG, Schertzer JD & Lynch GS (2008). IGF-I analogue protects muscles of dystrophic mdx mice from contraction-mediated damage. Experimental Physiology 93, 1190-1198.
  25. Ryall JG & Lynch GS (2008). The potential and the pitfalls of the development of b2-adrenoceptor agonists as drugs for the management of muscle wasting. Pharmacology & Therapeutics 120, 219-232.
  26. Ryall JG, Schertzer JD, Murphy KT, Allen AM & Lynch GS (2008). Chronic b2-adrenoceptor stimulation impairs cardiac relaxation via reduced SR Ca2+-ATPase activity. American Journal of Physiology; Heart and Circulatory Physiology 294, H2587-H2595.
  27. Ryall JG, Schertzer JD, Alabakis TM, Gehrig SM, Plant DR & Lynch GS (2008). Intramuscular b2-agonist administration enhances early regeneration and functional repair after myotoxic injury in rat skeletal muscle. Journal of Applied Physiology 105, 165-172.
  28. Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS & Muscat GEO (2008). The orphan nuclear receptor, NOR-1, a target of b-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle. Endocrinology 149, 2853-2865.
  29. Lynch GS, Schertzer JD & Ryall JG (2008). Anabolic agents for improving muscle regeneration and function after injury. Clinical and Experimental Pharmacology and Physiology 35, 852-858.
  30. Lynch GS & Ryall JG (2008). Role of b-adrenoceptor signaling in skeletal muscle – implications for muscle wasting and disease. Physiological Reviews 88, 729-767.
  31. Schertzer JD, Gehrig SM, Ryall JG & Lynch GS (2007). Modulation of IGF-I and IGFBP interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice. American Journal of Pathology 171, 1180-1188.
  32. Ryall JG, Schertzer JD & Lynch GS (2008). Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness. Biogerontology 9, 213-228.
  33. Ryall JG, Schertzer JD & Lynch GS (2007). Attenuation of age-related muscle wasting and weakness in rats after formoterol treatment: therapeutic implications for sarcopenia. Journals of Gerontology: Series A 62, 813-823.
  34. Lynch GS, Schertzer JD & Ryall JG (2007). Therapeutic approaches for muscle wasting disorders. Pharmacology & Therapeutics 113, 461-487.
  35. Harcourt LJ, Schertzer JD, Ryall JG & Lynch GS (2007). Low dose formoterol administration improves muscle function in dystrophic mdx mice without increasing fatigue. Neuromuscular Disorders 17, 47-55.
  36. Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS & Muscat GEO (2006). The orphan nuclear receptor, nor-1, is a target of β-adrenergic signaling in skeletal muscle. Endocrinology 147, 5217-5227.
  37. Schertzer JD, Ryall JG & Lynch GS (2006). Systemic administration of IGF-1 enhances oxidative status and reduces contraction induced injury in skeletal muscles of mdx mice. American Journal of Physiology; Endocrinology and Metabolism 291, E499-E505.
  38. Ryall JG, Sillence MN & Lynch GS (2006). Systemic administration of b2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses. British Journal of Pharmacology 147, 587-595.
  39. Ryall JG,* Gregorevic P,* Plant DR, Sillence MN & Lynch GS (2005). Chronic b2-agonist administration affects cardiac function of adult but not old rats, independent of b-adrenoceptor density. American Journal of Physiology; Heart and Circulatory Physiology 289, 344-349. *These authors contributed equally to this work.
  40. Schertzer JD, Plant DR, Ryall JG, Beitzel F, Stupka N & Lynch GS (2005). b2-agonist administration increases sarcoplasmic reticulum Ca2+-ATPase activity in aged rat skeletal muscle. American Journal of Physiology; Endocrinology and Metabolism 288, 526-533.
  41. Ryall JG, Plant DR, Gregorevic P, Sillence MN & Lynch GS (2004). b2-Agonist administration reverses muscle wasting and improves muscle function in aged rats. Journal of Physiology 555, 175-188.
  42. Ryall JG, Plant DR & Lynch GS (2004).  Making old muscles young again: a therapeutic role for b2-agonists? Physiology News 56, 33-35.
  43. Beitzel F, Gregorevic P, Ryall JG, Plant DR, Sillence MN & Lynch GS (2004). b2-Adrenoceptor agonist fenoterol enhances functional repair of regenerating rat skeletal muscle following injury. Journal of Applied Physiology 96, 1385-1392.
  44. Ryall JG, Gregorevic P, Plant DR, Sillence MN & Lynch GS (2002). b2-agonist fenoterol has greater effects on contractile function of rat skeletal muscles than clenbuterol. American Journal of Physiology; Regulatory, Integrative and Comparative Physiology 283, 1386-1394.

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